Mouse anti-sTn monoclonal antibody (Catalog # TVBP002) for inflammatory cell ICC and inflammatory tissue IHC assay
sTn antigen (sialyl-N-acetyl-galactosamine O-linked to serine or threonine, Sialyl-galNAc-O-Ser/Thr), a mucin-type O-linked glycan, is a well-established cell surface marker for inflammatory tissues. Its elevated levels have been correlated with inflammation
sTn is the surface marker of inflammatory cells and tissues. Applying our mouse anti-sTn monoclonal antibody (Catglog # TVBP002), we were able to detect a significant increase in the levels of sTn antigen in human gingival fibroblasts under the induction of TNF-α (30 ng/ml) for 48 hours (fig. 1). We also observed an increase of sTn in experimental periodontitis (fig. 2).
Figure 1. sTn was induced in human gingival fibroblasts with TNF-a treatment (30 ng/ml) for 48 hours
Figure 2. sTn was detected in experimental periodontitis using our mouse anti-sTn monoclonal antibody (Catalog # TVBP002) for inflammatory tissue IHC assay.